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KMID : 0606920070150010052
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Biomolecules & Therapeutics
2007 Volume.15 No. 1 p.52 ~ p.57
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Effects of Proton on Lysolipid-induced Actions in OGR1-subfamily GPCRs
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Lim Sung-Mee
Im Dong-Soon
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Abstract
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Lysolipids such as lysophosphatidylcholine (LPC), sphingosylphosphorylcholine (S PC), galactosylsphingosine (psychosine) have been matched as ligands for OGR1-subfamily G-protein-coupled receptors (GPCR), consisted of OGR1, GPR4, G2A, and TDAG8. Recently, those members of GPCRS have been reported as proton-sensing GPCRs. We used Jurkat T cells, which express four members of OGR1 subfamily GPCRs endogenously to investigate effects of proton on lysolipid-induced several cellular events. We found no significant effect of proton on the lysolipid-induced $Ca^{2+}$ increase and ROS production in Jurkat T cells. Further investigation is necessary to clarify the relationship of lysolipid and proton on the OGR1-subfamily GPCRs
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KEYWORD
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lysolipid, proton, G-protein-coupled receptor, sphingosylphosphorylcholine, lysophosphatidylcholine, psychosine
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